No AZF deletion in 160 patients with testicular germ cell neoplasia
نویسندگان
چکیده
منابع مشابه
No AZF deletion in 160 patients with testicular germ cell neoplasia.
Testicular germ cell cancer is aetiologically linked to genital malformations and male infertility and is most probably caused by a disruption of embryonic programming and gonadal development during fetal life. In some cases, germ cell neoplasia is associated with a relative reduction of Y chromosomal material (e.g. 45,X/46,XY) or other abnormalities of the Y chromosome. The euchromatic long ar...
متن کاملAbsence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors.
OBJECTIVES To investigate the frequency of azoospermia factor (AZF) deletions in Dutch patients with testicular germ cell tumors (TGCTs). Reduced fertility is associated with TGCTs and reduced fertility and TGCTs might share genetic risk factors according to the testicular dysgenesis hypothesis. Up to 8% of infertility and reduced fertility in the general male population can be explained by the...
متن کاملPure testicular carcinoid associated with intratubular germ cell neoplasia.
This case report describes for the first time a case of pure testicular carcinoid pre-aortic lymph node metastases in a 25 year old patient with carcinoid syndrome. The simultaneous occurrence of intratubular germ cell neoplasia in the surrounding testicular tissue was identified by OCT4 and placental-like alkaline phosphatase positivity. This confirmed that the tumour had a germ cell origin in...
متن کاملGerm Cell ; TGCT , Testicular Germ Cell Tumor ; SNV , Single Nucleotide Variant ; BAF , B - Allele Frequency ; GCNIS , Germ Cell Neoplasia In
Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain genome integrity. Despite constant turnover, spermatogonia very rarely form tumors, so-called spermatocytic tumors (SpT). In line with the previous id...
متن کاملPrimordial Germ Cell ; TGCT , Testicular Germ Cell Tumor ; SNV , Single Nucleotide Variant ; BAF , B - Allele Frequency ; GCNIS , Germ Cell Neoplasia
Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain genome integrity. Despite constant turnover, spermatogonia very rarely form tumors, so-called spermatocytic tumors (SpT). In line with the previous id...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2003
ISSN: 1460-2407
DOI: 10.1093/molehr/gag069